Explanation of neuromodulation:
The term “neuromodulation” has multiple meanings for different audiences. We focus here on non-invasive systems that stimulate one or more regions of the brain in different physical ways at different frequencies or change their neuronal dynamics. The neuromodulation systems we are developing or planning are based on sensory stimulation rather than electrical. They are designed for therapy, but can also contribute to diagnostic assessments. The role of neural rhythms has become very influential in theories and models of brain function, studies of consciousness, etc. In clinical practice, however, brain diseases are often not considered in the context of dysfunctional rhythms in brain activity (epilepsy is a notable exception). Instead, the focus is usually on biochemical pathways and processes. The goal of sensory neuromodulation systems, however, is to alter oscillatory dynamics so that they are ideally closer to a pre-disease state. Specific effects on the biochemical pathways affected by this are of limited concern. We apply a mastery principle in which the presence of externally stimulating oscillations (acoustic, visual, mechanical) at a specific frequency dominates various underlying biochemical processes in a hierarchical manner and not vice versa. However, sensory neuromodulation does not represent a “one-way street”, but continuously interacts with the biochemical processes accompanying the disturbed brain function.
Examples of potential applications include:
- Alzheimer’s disease
- Parkinson’s disease, also essential tremor
- POst COVID-Syndrome
- Severe depression
- Pain, including migraine
- ME/CFS, chronic fatigue syndrome
- Fibromyalgia
- Tinnitus
- Schizophrenia
- Sleep disorders
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